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Janice V Darlington Selected Research

3- (3- tert- butylsulfanyl- 1- (4- (6- methoxypyridin- 3- yl)benzyl)- 5- (pyridin- 2- ylmethoxy)- 1H- indol- 2- yl)- 2,2- dimethylpropionic acid

12/2009Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation.

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Janice V Darlington Research Topics

Disease

2Inflammation (Inflammations)
08/2010 - 12/2009
1Asthma (Bronchial Asthma)
12/2009
1Pneumonia (Pneumonitis)
12/2009
1Shock
12/2009

Drug/Important Bio-Agent (IBA)

2ZymosanIBA
08/2010 - 12/2009
2Blood Proteins (Serum Proteins)IBA
08/2010 - 12/2009
2propionic acid (potassium propionate)IBA
08/2010 - 12/2009
1Proteins (Proteins, Gene)FDA Link
08/2010
1Leukotriene B4IBA
08/2010
1Lipoxygenase (Lipoxygenase-1)IBA
08/2010
1Eosinophil PeroxidaseIBA
12/2009
15-Lipoxygenase-Activating ProteinsIBA
12/2009
13- (3- tert- butylsulfanyl- 1- (4- (6- methoxypyridin- 3- yl)benzyl)- 5- (pyridin- 2- ylmethoxy)- 1H- indol- 2- yl)- 2,2- dimethylpropionic acidIBA
12/2009
1OvalbuminIBA
12/2009
1Interleukin-5 (Interleukin 5)IBA
12/2009